A Catalyst Free Surfactant Mediated Multicomponent Synthesis of Quinazolinone Derivatives in Aqueous Media

A versatile and green synthetic protocol has been developed for synthesis of substituted quinazolinone spiroquinazolinone heterocycles effectively via a combined surfactant mediated system. The use Surfactant, water as reaction medium, room temperature, high yield ease purification made the process very effective ecofriendly in nature. To demonstrate wide scope Isatoic anhydride Isatin used reactants different sets reactions that leads to formation Quinazolinones spiroquinazolinones. total 12 derivatives prepared characterized by all spectroscopic data. presents better environmentally efficient methodology get these heterocycles.